| 08/19/2021 | vs Valparaiso | W | 1-0 | 1-0-0, 0-0-0 | 0-0-0 | 523 | Jordyn Levy (1) (Camille Hamm)
|
| 08/22/2021 | at Notre Dame | T | 0-0 | 1-0-1, 0-0-0 | 0-0-0 | 825 | Â |
| 08/26/2021 | vs UT Martin | W | 1-0 | 2-0-1, 0-0-0 | 0-0-0 | 403 | Avery Lockwood (1) (Hanna Nemeth)
|
| 08/29/2021 | at Memphis | L | 0-1 | 2-1-1, 0-0-0 | 0-0-0 | 218 | Â |
| 09/02/2021 | vs Western Mich. | W | 2-1 | 3-1-1, 0-0-0 | 0-0-0 | 472 | Jen Blitchok (1) (Alaina Kalin) Jordyn Levy (2) (Jen Blitchok)
|
| 09/05/2021 | vs Southeast Mo. St. | W | 6-0 | 4-1-1, 0-0-0 | 0-0-0 | 533 | Jen Blitchok (2) (Anna Bennett) Jordyn Levy (3) (Jen Blitchok) Avery Lockwood (2) (Alaina Kalin) Anna Bennett (1) Sofia Black (1) (Karlee Luker) Bria Telemaque (1) (Melanie Forbes)
|
| 09/09/2021 | vs Murray St. | W | 4-0 | 5-1-1, 0-0-0 | 0-0-0 | 511 | Jordyn Levy (4) (Oliwia Wos) Paige Webber (3) (Melanie Forbes , Camille Hamm) Paige Webber (3) (Camille Hamm) Paige Webber (3) (Jen Blitchok)
|
| 09/12/2021 | at Kansas St. | W | 3-0 | 6-1-1, 0-0-0 | 0-0-0 | 683 | Anna Bennett (2) (Paige Webber) Avery Lockwood (3) Jen Blitchok (3) (Hanna Nemeth)
|
| 09/19/2021 | vs Michigan St. | L | 0-1 | 6-2-1, 0-1-0 | 0-1-0 | 678 | Â |
| 09/23/2021 | vs Iowa | W | 2-0 | 7-2-1, 1-1-0 | 1-1-0 | 689 | Anna Bennett (3) (Jordyn Levy) Paige Webber (4) (Jordyn Levy)
|
| 09/26/2021 | vs Illinois | W | 2-1 | 8-2-1, 2-1-0 | 2-1-0 | 623 | Paige Webber (5) (Melanie Forbes) Melanie Forbes (1) (Jen Blitchok)
|
| 09/30/2021 | at Ohio State | T | 1-1 | 8-2-2, 2-1-1 | 2-1-1 | 411 | Jen Blitchok (4) (Anna Bennett)
|
| 10/03/2021 | vs Michigan | T | 0-0 | 8-2-3, 2-1-2 | 2-1-2 | 0 | Â |
| 10/10/2021 | at Northwestern | W | 1-0 | 9-2-3, 3-1-2 | 3-1-2 | 869 | Megan Wampler (1) (Oliwia Wos)
|
| 10/13/2021 | at Penn St. | L | 0-3 | 9-3-3, 3-2-2 | 3-2-2 | 547 | Â |
| 10/17/2021 | at Maryland | T | 0-0 | 9-3-4, 3-2-3 | 3-2-3 | 1234 | Â |
| 10/21/2021 | vs Rutgers | L | 0-2 | 9-4-4, 3-3-3 | 3-3-3 | 737 | Â |
| 10/24/2021 | at Purdue | L | 0-2 | 9-5-4, 3-4-3 | 3-4-3 | 360 | Â |